Journal article
IV bolus, maintenance and medication carrier fluid in children with community-acquired sepsis: a multicentre cohort study
E Long, C Selman, ML Borland, S George, S Jani, E Tan, N Phillips, A Kochar, S Craig, A Lithgow, E Whyte, B Gelbart, S McNab, S Dalziel, F Balamuth, SL Weiss, N Kuppermann, A Williams, FE Babl
Archives of Disease in Childhood | Published : 2026
Abstract
Objectives: We set out to describe the amount of fluid administered within the first 24 hours of sepsis treatment with an exploratory analysis of associations. Design: This prospective observational study used data from the Sepsis Epidemiology in Australian and New Zealand Emergency Departments Study, collected from 2021 to 2023. Patients: Participants were children aged 0 years to 55 mL/kg vs <15 mL/kg bolus fluid: 20.5, 95% CI 8.0 to 52.5; p<0.001). Conclusion: Although maintenance fluids accounted for the largest proportion of total fluid volume, bolus fluids showed the strongest association with in-hospital mortality in unadjusted analyses.
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Awarded by National Health and Medical Research Council